In 1969, cyclamates were banned in the U.S. Cyclamate is a non-caloric sweetener discovered in 1937. It has been widely used as a tabletop sweetener, in sugar-free beverages, in baked goods and other low-calorie foods, particularly in combination with saccharin. The ban was based on concern raised by experiments showing bladder tumors appeared in laboratory rats fed large doses of cyclamate. Following new experiments, in June 1985, the National Academy of Sciences affirmed the FDA's Cancer Assessment Committee's latest conclusion: "the totality of the evidence from studies in animals does not indicate that cyclamate or its major metabolite cyclohexylamine is carcinogenic by itself." Cyclamate is approved for use in more than 50 countries.